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 Basic information of Glutathione

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Join date : 2011-07-11

PostSubject: Basic information of Glutathione   Wed Jul 13, 2011 12:26 pm

Glutathione, with its CAS register number of 70-18-8, is also known as L-Glutathione reduced, Glycineγ-L-glutamyl-L-cysteinyl-glycine and so on. And its IUPAC name is (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid. For a kind of white crystalline powder, this chemical is soluble in water, dilute alcohol, liquid ammonia and dimethyl formamide while insoluble in ethanol, ether and acetone, and its solid is relatively stable in RT. This chemical is a kind of tripeptide which is with many roles in cells. It conjugates to drugs to make them more soluble for excretion, and it is a cofactor for some enzymes, or is involved in protein disulfide bond rearrangement and reduces peroxides. When you store it, you should keep it sealed. 1. Properties Of Glutathione Properties of Glutathione are as below: (1)# of Rule of 5 Violations: 1; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC(pH 7.4): 1; (6)#H bond acceptors: 9; (7)#H bond donors: 6; (Cool#Freely RotatingBonds: 11; (9)Polar Surface Area: 197.62 Å2; (10)Index of Refraction: 1.572; (11)Molar Refractivity: 70.105 cm3; (12)Molar Volume: 213.204 cm3; (13)Polarizability: 27.792 10-24cm3; (14)Surface Tension: 69.366 dyne/cm; (15) Density: 1.441 g/cm3; (16)Flash Point: 410.102 °C; (17)Enthalpy of Vaporization: 119.618 kJ/mol; (18)Boiling Point: 754.492 °C at 760 mmHg. 2. Safety Information Of Glutathione When you are dealing with Glutathione, you should be careful. This chemical is irritating to eyes, respiratory system and skin which may cause inflammation to the skin or other mucous membranes. Therefore, you should wear suitable protective clothing, gloves and eye/face protection and avoid contact with skin and eyes. If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice and you should take off immediately all contaminated clothing.
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